ZONTIVITY® (vorapaxar) helps reduce your cardiovascular risk

ZONTIVITY is a prescription medicine used to treat people who have:

  • had a heart attackIcon of a heart.
  • or
  • reduced blood flow in their legs (peripheral arterial disease, or PAD)Icon of a leg.

ZONTIVITY is used with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death.

Note: While ZONTIVITY reduces the chance of a first stroke, you should not take it if you have previously had a stroke or transient ischemic attack (TIA).

Woman smiling with her arms folded. Not an actual patient

How does ZONTIVITY work?

ZONTIVITY, aspirin, and clopidogrel are all a type of medication called antiplatelet therapy.

Icon of platelets sticking together to form a blood clot.

These medications work by preventing platelets from sticking together to form a blood clot.

Icon of platelets separated from each other.

Aspirin and clopidogrel each prevent platelets from sticking together to form blood clots in different ways.

ZONTIVITY works differently from aspirin and clopidogrel to prevent platelets from forming blood clots that could cause a heart attack.

Save on your ZONTIVITY copay
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Proven to lower your cardiovascular risk

Icon of an arrow pointing downward.

In a clinical study of more than 20,000 people who have had a heart attack or have peripheral arterial disease (PAD), ZONTIVITY with aspirin and/or clopidogrel was better than aspirin and/or clopidogrel alone at lowering the chance of the following:

  • Heart attack
  • First stroke
  • Death due to problems with the heart or blood vessels
  • Urgent procedure to address blocked arteries supplying blood to the heart

Learn why having PAD or a previous heart attack increases your cardiovascular risk:

PAD heart attack

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Smiling man. Not an actual patient

How to take ZONTIVITY

Take ZONTIVITY exactly as prescribed by your doctor. ZONTIVITY is taken:

  • Take ZONTIVITY® just once a day with or without food along with aspirin, clopidogrel, or both.
  • With aspirin, clopidogrel, or both,as prescribed by your doctor

Do not stop taking ZONTIVITY without first talking
to the doctor who prescribed it for you. If you take too much ZONTIVITY, call your doctor,
or go to the nearest emergency room right away.

Side effects and safety

The most important side effect to be aware of is that ZONTIVITY (and similar drugs) can cause bleeding that can be serious and lead to death. Call your doctor right away if you have any of these signs or symptoms of bleeding while taking ZONTIVITY:

  • Bleeding that is severe or that you cannot control
  • Pink, red, or brown urine
  • Vomiting blood or your vomit looks like “coffee grounds”
  • Red or black stools (looks like tar)
  • Coughing up blood or blood clots

While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped:

  • You may bruise and bleed more easily (nose bleeds may be common)
  • It will take longer than usual for any bleeding to stop
Download the medication guide to learn more about ZONTIVITY
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Indication

ZONTIVITY is a prescription medicine used to treat people who have

  • had a heart attack or
  • reduced blood flow in their legs (peripheral arterial disease).
Important Safety Information

ZONTIVITY is used with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death but ZONTIVITY (and similar drugs) can cause bleeding that can be serious and lead to death.

While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped:

  • you may bruise and bleed more easily (nose bleeds may be common)
  • it will take longer than usual for any bleeding to stop.

Call your doctor right away if you have any of these signs or symptoms of bleeding while taking ZONTIVITY:

  • bleeding that is severe or that you cannot control
  • pink, red, or brown urine
  • vomiting blood or your vomit looks like "coffee grounds"
  • red or black stools (looks like tar)
  • coughing up blood or blood clots.

Do not take ZONTIVITY if you:

  • have had a stroke or "mini stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding in your brain
  • currently have unusual bleeding, such as bleeding in your head, stomach or intestines (an ulcer).

If you have a stroke, TIA, or bleeding in your brain while taking ZONTIVITY your doctor should stop your treatment with ZONTIVITY. Follow your doctor's instructions about stopping ZONTIVITY.

Take ZONTIVITY exactly as prescribed by your doctor. Do not stop taking ZONTIVITY without first talking to the doctor who prescribed it for you.

Before you take ZONTIVITY, tell your doctor if you:

  • have had bleeding problems or history of stomach ulcers
  • have had a stroke or “mini-stroke” (also known as transient ischemic attack or TIA)
  • have had bleeding (hemorrhage) in your brain
  • have had any recent serious injury or surgery
  • plan to have surgery or a dental procedure
  • have kidney problems or severe liver problems
  • are pregnant or plan to become pregnant. It is not known if ZONTIVITY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZONTIVITY passes into your breast milk. You and your doctor should decide if you will take ZONTIVITY or breastfeed. You should not do both.

Tell all of your doctors and dentists that you are taking ZONTIVITY with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel. They should talk to the doctor who prescribed ZONTIVITY for you before you have any surgery or dental procedure.

The possible side effects of ZONTIVITY include:

  • Anemia (low level of red blood cells)
  • Depression
  • Rash

These are not all the possible side effects of ZONTIVITY.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary or herbal supplements. Taking ZONTIVITY with certain other medicines may increase your risk of bleeding and may affect how ZONTIVITY works.

The risk information provided here is not comprehensive. To learn more, talk about ZONTIVITY with your pharmacist or other health care providers. The product information can be found at www.zontivity.com or 1-866-207-6592.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for Medication Guide, including Important Warning about bleeding risk.


READ LESS
Indication

ZONTIVITY is a prescription medicine used to treat people who have

  • had a heart attack or
  • reduced blood flow in their legs (peripheral arterial disease).
READ MORE
READ LESS
Important Safety Information

ZONTIVITY is used with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death but ZONTIVITY (and similar drugs) can cause bleeding that can be serious and lead to death.

While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped:

  • you may bruise and bleed more easily (nose bleeds may be common)
  • it will take longer than usual for any bleeding to stop.

Call your doctor right away if you have any of these signs or symptoms of bleeding while taking ZONTIVITY:

  • bleeding that is severe or that you cannot control
  • pink, red, or brown urine
  • vomiting blood or your vomit looks like "coffee grounds"
  • red or black stools (looks like tar)
  • coughing up blood or blood clots.

Do not take ZONTIVITY if you:

  • have had a stroke or "mini stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding in your brain
  • currently have unusual bleeding, such as bleeding in your head, stomach or intestines (an ulcer).

If you have a stroke, TIA, or bleeding in your brain while taking ZONTIVITY your doctor should stop your treatment with ZONTIVITY. Follow your doctor's instructions about stopping ZONTIVITY.

Take ZONTIVITY exactly as prescribed by your doctor. Do not stop taking ZONTIVITY without first talking to the doctor who prescribed it for you.

Before you take ZONTIVITY, tell your doctor if you:

  • have had bleeding problems or history of stomach ulcers
  • have had a stroke or “mini-stroke” (also known as transient ischemic attack or TIA)
  • have had bleeding (hemorrhage) in your brain
  • have had any recent serious injury or surgery
  • plan to have surgery or a dental procedure
  • have kidney problems or severe liver problems
  • are pregnant or plan to become pregnant. It is not known if ZONTIVITY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZONTIVITY passes into your breast milk. You and your doctor should decide if you will take ZONTIVITY or breastfeed. You should not do both.

Tell all of your doctors and dentists that you are taking ZONTIVITY with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel. They should talk to the doctor who prescribed ZONTIVITY for you before you have any surgery or dental procedure.

The possible side effects of ZONTIVITY include:

  • Anemia (low level of red blood cells)
  • Depression
  • Rash

These are not all the possible side effects of ZONTIVITY.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary or herbal supplements. Taking ZONTIVITY with certain other medicines may increase your risk of bleeding and may affect how ZONTIVITY works.

The risk information provided here is not comprehensive. To learn more, talk about ZONTIVITY with your pharmacist or other health care providers. The product information can be found at www.zontivity.com or 1-866-207-6592.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for Medication Guide, including Important Warning about bleeding risk.

READ MORE