About ZONTIVITY About PAD and Heart Attack

ZONTIVITY® (vorapaxar) can help change your Cardiovascular Future

If you’ve had a heart attack or have peripheral arterial disease (PAD), ZONTIVITY taken with aspirin and/or clopidogrel may lower your chance of heart attack, stroke, or death.

See how ZONTIVITY can help Access Your Zontivity Co-pay card
Learn how Ellen is protecting her heart because of her PAD Not an actual patient
See how Bob is trying to prevent a second heart attack Not an actual patient

I learned that having peripheral arterial disease can be a big threat to my heart, so I’m taking steps to protect it.

When the thought of walking through Orlando with my grandkids felt more daunting than exciting, I knew it was time to finally quit smoking for good and speak to my doctor about my leg problems. I was diagnosed with PAD, and learned that it increases my risk for heart attack and stroke. I never would have thought my leg pain could be so dangerous. Speaking up about my PAD symptoms led my doctor to prescribe ZONTIVITY with aspirin to help reduce my cardiovascular risk.

See how ZONTIVITY can help Learn more about PAD
Smiling woman holding a bag of groceries. Not an actual patient

I don’t want
a heart attack to define my future.

Having a heart attack was the scariest thing I’ve ever experienced. I never want to put myself or my family through that again, but I know I’m now at a much higher risk of having another one. The road to recovery will be long, and my diabetes won’t make it easy. To help lower my risk of having another heart attack or a stroke, my doctor prescribed ZONTIVITY with aspirin and Plavix®.

See how ZONTIVITY can help
Learn more about heart attacks
Man holding his coat over his shoulder. Not an actual patient
Indication

ZONTIVITY is a prescription medicine used to treat people who have

  • had a heart attack or
  • reduced blood flow in their legs (peripheral arterial disease).

ZONTIVITY is used with aspirin and/or clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death

Important Safety Information

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT ZONTIVITY?

ZONTIVITY is used to lower your chance of having another serious problem with your heart or blood vessels, but ZONTIVITY (and similar drugs) can cause bleeding that can be serious and lead to death.

Call your doctor right away if you have any of these signs or symptoms of bleeding while taking ZONTIVITY:

  • bleeding that is severe or that you cannot control
  • pink, red, or brown urine
  • vomiting blood or your vomit looks like "coffee grounds"
  • red or black stools (looks like tar)
  • coughing up blood or blood clots.

While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped:

  • you may bruise and bleed more easily (nose bleeds may be common)
  • it will take longer than usual for any bleeding to stop.

Do not take ZONTIVITY if you:

  • have had a stroke or "mini stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding in your brain
  • currently have unusual bleeding, such as bleeding in your head, stomach or intestines (an ulcer).

If you have a stroke, TIA, or bleeding in your brain while taking ZONTIVITY your doctor should stop your treatment with ZONTIVITY. Follow your doctor's instructions about stopping ZONTIVITY.

Take ZONTIVITY exactly as prescribed by your doctor. Do not stop taking ZONTIVITY without first talking to the doctor who prescribed it for you.

Before you take ZONTIVITY, tell your doctor if you:

  • have had bleeding problems or history of stomach ulcers
  • have had a stroke or "mini-stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding (hemorrhage) in your brain
  • have had any recent serious injury or surgery
  • plan to have surgery or a dental procedure
  • have kidney problems or severe liver problems
  • are pregnant or plan to become pregnant. It is not known if ZONTIVITY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZONTIVITY passes into your breast milk. You and your doctor should decide if you will take ZONTIVITY or breastfeed. You should not do both.

Tell all of your doctors and dentists that you are taking ZONTIVITY with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel. They should talk to the doctor who prescribed ZONTIVITY for you before you have any surgery or dental procedure.

The possible side effects of ZONTIVITY include:

  • Bleeding that can be serious and lead to death (see above)
  • Anemia (low level of red blood cells)
  • Depression
  • Rash

These are not all the possible side effects of ZONTIVITY.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary or herbal supplements. Taking ZONTIVITY with certain other medicines may increase your risk of bleeding and may affect how ZONTIVITY works.

The risk information provided here is not comprehensive. To learn more, talk about ZONTIVITY with your pharmacist or other health care providers. The product information can be found at www.zontivity.com or call at 1-800-988-6115.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for Medication Guide, including Important Warning about bleeding risk.


READ LESS
Indication

ZONTIVITY is a prescription medicine used to treat people who have

  • had a heart attack or
  • reduced blood flow in their legs (peripheral arterial disease).

ZONTIVITY is used with aspirin and/or clopidogrel to lower your chance of having another serious problem with your heart or blood vessels, such as heart attack, stroke, or death

READ MORE
READ LESS
Important Safety Information

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT ZONTIVITY?

ZONTIVITY is used to lower your chance of having another serious problem with your heart or blood vessels, but ZONTIVITY (and similar drugs) can cause bleeding that can be serious and lead to death.

Call your doctor right away if you have any of these signs or symptoms of bleeding while taking ZONTIVITY:

  • bleeding that is severe or that you cannot control
  • pink, red, or brown urine
  • vomiting blood or your vomit looks like "coffee grounds"
  • red or black stools (looks like tar)
  • coughing up blood or blood clots.

While you take ZONTIVITY and for about 4 weeks after your treatment with ZONTIVITY is stopped:

  • you may bruise and bleed more easily (nose bleeds may be common)
  • it will take longer than usual for any bleeding to stop.

Do not take ZONTIVITY if you:

  • have had a stroke or "mini stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding in your brain
  • currently have unusual bleeding, such as bleeding in your head, stomach or intestines (an ulcer).

If you have a stroke, TIA, or bleeding in your brain while taking ZONTIVITY your doctor should stop your treatment with ZONTIVITY. Follow your doctor's instructions about stopping ZONTIVITY.

Take ZONTIVITY exactly as prescribed by your doctor. Do not stop taking ZONTIVITY without first talking to the doctor who prescribed it for you.

Before you take ZONTIVITY, tell your doctor if you:

  • have had bleeding problems or history of stomach ulcers
  • have had a stroke or "mini-stroke" (also known as transient ischemic attack or TIA)
  • have had bleeding (hemorrhage) in your brain
  • have had any recent serious injury or surgery
  • plan to have surgery or a dental procedure
  • have kidney problems or severe liver problems
  • are pregnant or plan to become pregnant. It is not known if ZONTIVITY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if ZONTIVITY passes into your breast milk. You and your doctor should decide if you will take ZONTIVITY or breastfeed. You should not do both.

Tell all of your doctors and dentists that you are taking ZONTIVITY with aspirin, with clopidogrel (Plavix®), or with aspirin and clopidogrel. They should talk to the doctor who prescribed ZONTIVITY for you before you have any surgery or dental procedure.

The possible side effects of ZONTIVITY include:

  • Bleeding that can be serious and lead to death (see above)
  • Anemia (low level of red blood cells)
  • Depression
  • Rash

These are not all the possible side effects of ZONTIVITY.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary or herbal supplements. Taking ZONTIVITY with certain other medicines may increase your risk of bleeding and may affect how ZONTIVITY works.

The risk information provided here is not comprehensive. To learn more, talk about ZONTIVITY with your pharmacist or other health care providers. The product information can be found at www.zontivity.com or call at 1-800-988-6115.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for Medication Guide, including Important Warning about bleeding risk.

READ MORE